Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action
Identifieur interne : 000494 ( Main/Exploration ); précédent : 000493; suivant : 000495Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action
Auteurs : Marta Gozzi ; Blagoje Murganic ; Dijana Dra A ; John Popp ; Peter Coburger ; Danijela Maksimovi Vani ; Sanja Mijatovi ; Evamarie Hey-HawkinsSource :
- Chemmedchem [ 1860-7179 ] ; 2019.
Abstract
The role of autophagy in cancer is often complex, ranging from tumor‐promoting to ‐suppressing effects. In this study, two novel hybrid molecules were designed, containing a ruthenacarborane fragment conjugated with a known modulator of autophagy, namely a quinoline derivative. The complex
Url:
DOI: 10.1002/cmdc.201900349
PubMed: 31675152
PubMed Central: 6973020
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000483
- to stream Pmc, to step Curation: 000483
- to stream Pmc, to step Checkpoint: 000450
- to stream Ncbi, to step Merge: 000B64
- to stream Ncbi, to step Curation: 000B64
- to stream Ncbi, to step Checkpoint: 000B64
- to stream Main, to step Merge: 000494
- to stream Main, to step Curation: 000494
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action</title><author><name sortKey="Gozzi, Marta" sort="Gozzi, Marta" uniqKey="Gozzi M" first="Marta" last="Gozzi">Marta Gozzi</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Murganic, Blagoje" sort="Murganic, Blagoje" uniqKey="Murganic B" first="Blagoje" last="Murganic">Blagoje Murganic</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Dra A, Dijana" sort="Dra A, Dijana" uniqKey="Dra A D" first="Dijana" last="Dra A">Dijana Dra A</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Popp, John" sort="Popp, John" uniqKey="Popp J" first="John" last="Popp">John Popp</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Coburger, Peter" sort="Coburger, Peter" uniqKey="Coburger P" first="Peter" last="Coburger">Peter Coburger</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Maksimovi Vani, Danijela" sort="Maksimovi Vani, Danijela" uniqKey="Maksimovi Vani D" first="Danijela" last="Maksimovi Vani">Danijela Maksimovi Vani</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Mijatovi, Sanja" sort="Mijatovi, Sanja" uniqKey="Mijatovi S" first="Sanja" last="Mijatovi">Sanja Mijatovi</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Hey Awkins, Evamarie" sort="Hey Awkins, Evamarie" uniqKey="Hey Awkins E" first="Evamarie" last="Hey-Hawkins">Evamarie Hey-Hawkins</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31675152</idno><idno type="pmc">6973020</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973020</idno><idno type="RBID">PMC:6973020</idno><idno type="doi">10.1002/cmdc.201900349</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000483</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000483</idno><idno type="wicri:Area/Pmc/Curation">000483</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000483</idno><idno type="wicri:Area/Pmc/Checkpoint">000450</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000450</idno><idno type="wicri:Area/Ncbi/Merge">000B64</idno><idno type="wicri:Area/Ncbi/Curation">000B64</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B64</idno><idno type="wicri:doubleKey">1860-7179:2019:Gozzi M:quinoline:conjugated:ruthenacarboranes</idno><idno type="wicri:Area/Main/Merge">000494</idno><idno type="wicri:Area/Main/Curation">000494</idno><idno type="wicri:Area/Main/Exploration">000494</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action</title><author><name sortKey="Gozzi, Marta" sort="Gozzi, Marta" uniqKey="Gozzi M" first="Marta" last="Gozzi">Marta Gozzi</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Murganic, Blagoje" sort="Murganic, Blagoje" uniqKey="Murganic B" first="Blagoje" last="Murganic">Blagoje Murganic</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Dra A, Dijana" sort="Dra A, Dijana" uniqKey="Dra A D" first="Dijana" last="Dra A">Dijana Dra A</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Popp, John" sort="Popp, John" uniqKey="Popp J" first="John" last="Popp">John Popp</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Coburger, Peter" sort="Coburger, Peter" uniqKey="Coburger P" first="Peter" last="Coburger">Peter Coburger</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Maksimovi Vani, Danijela" sort="Maksimovi Vani, Danijela" uniqKey="Maksimovi Vani D" first="Danijela" last="Maksimovi Vani">Danijela Maksimovi Vani</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Mijatovi, Sanja" sort="Mijatovi, Sanja" uniqKey="Mijatovi S" first="Sanja" last="Mijatovi">Sanja Mijatovi</name><affiliation><nlm:aff id="cmdc201900349-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Hey Awkins, Evamarie" sort="Hey Awkins, Evamarie" uniqKey="Hey Awkins E" first="Evamarie" last="Hey-Hawkins">Evamarie Hey-Hawkins</name><affiliation><nlm:aff id="cmdc201900349-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Chemmedchem</title><idno type="ISSN">1860-7179</idno><idno type="eISSN">1860-7187</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The role of autophagy in cancer is often complex, ranging from tumor‐promoting to ‐suppressing effects. In this study, two novel hybrid molecules were designed, containing a ruthenacarborane fragment conjugated with a known modulator of autophagy, namely a quinoline derivative. The complex <italic>closo</italic>‐[3‐(<italic>η</italic><sup>6</sup>‐<italic>p</italic>‐cymene)‐1‐(quinolin‐8‐yl‐acetate)‐3,1,2‐RuC<sub>2</sub>B<sub>9</sub>H<sub>10</sub>] (<bold>4</bold>) showed a dual mode of action against the LN229 (human glioblastoma) cell line, where it inhibited tumor‐promoting autophagy, and strongly inhibited cell proliferation, <italic>de facto</italic> blocking cellular division. These results, together with the tendency to spontaneously form nanoparticles in aqueous solution, make complex <bold>4</bold> a very promising drug candidate for further studies <italic>in vivo</italic>, for the treatment of autophagy‐prone glioblastomas.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Coburger, Peter" sort="Coburger, Peter" uniqKey="Coburger P" first="Peter" last="Coburger">Peter Coburger</name><name sortKey="Dra A, Dijana" sort="Dra A, Dijana" uniqKey="Dra A D" first="Dijana" last="Dra A">Dijana Dra A</name><name sortKey="Gozzi, Marta" sort="Gozzi, Marta" uniqKey="Gozzi M" first="Marta" last="Gozzi">Marta Gozzi</name><name sortKey="Hey Awkins, Evamarie" sort="Hey Awkins, Evamarie" uniqKey="Hey Awkins E" first="Evamarie" last="Hey-Hawkins">Evamarie Hey-Hawkins</name><name sortKey="Maksimovi Vani, Danijela" sort="Maksimovi Vani, Danijela" uniqKey="Maksimovi Vani D" first="Danijela" last="Maksimovi Vani">Danijela Maksimovi Vani</name><name sortKey="Mijatovi, Sanja" sort="Mijatovi, Sanja" uniqKey="Mijatovi S" first="Sanja" last="Mijatovi">Sanja Mijatovi</name><name sortKey="Murganic, Blagoje" sort="Murganic, Blagoje" uniqKey="Murganic B" first="Blagoje" last="Murganic">Blagoje Murganic</name><name sortKey="Popp, John" sort="Popp, John" uniqKey="Popp J" first="John" last="Popp">John Popp</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000494 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000494 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6973020
|texte= Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31675152" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |